Publications
Preprints
2. A. Nguyen, J. B. Heim, G. Cordara, M. C. Chan, H. Johannesen, C. Charlesworth, M. Li, C. M. Azumaya, B. Madden, U. Krengel, others, “Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A”, In review. Preprint
1. H. J. Young*, M. C. Chan*, B. Selvam, S. K. Szymanski, D. Shukla, E. Procko, “Deep mutagenesis of a neurotransmitter transporter for uptake of a non-native substrate informs how sequence features relate to conformational dynamics”, In review. Preprint
Peer-Reviewed Manuscripts
12. J. A. Hollis, M. C. Chan, H. S. Malik, M. G. Campbell, “Molecular exaptation by the integrin αI domain”, Science Advances, 11(37), eadx9567, (2025). DOI
11. H. Osuga*†, M. C. Chan*†, K. Brower*, L. J. Ray, J. T. Chowning, “Ten simple rules for running a virtual program to introduce computational biology at the high school level”, PLOS Computational Biology, 21(12), e1013830, (2025). DOI
10. R. Gen, A. Addetia, D. Asarnow, Y. Park, J. Quispe, M. C. Chan, J. T. Brown, J. Lee, M. G. Campbell, C. P. Lapointe, others, “SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals”, Cell Reports, 44(5), (2025). DOI
9. M. C. Chan, Y. Alfawaz, A. Paul, D. Shukla, “Molecular insights into the elevator-type mechanism of the cyanobacterial bicarbonate transporter BicA”, Biophysical Journal, 124(2), 379–392, (2025). DOI
8. M. C. Chan, D. Shukla, “The effects of N-linked glycosylation on SLC6 transporters”, Journal of Chemical Information and Modeling, 63(9), 2748–2758, (2023). DOI
Featured on the cover of Journal of Chemical Information and Modeling.
7. M. C. Chan, K. K. Chan, E. Procko, D. Shukla, “Machine learning guided design of high affinity ACE2 decoys for SARS-CoV-2 neutralization”, The Journal of Physical Chemistry B, 127(9), 1995–2001, (2023). DOI
6. M. C. Chan, E. Procko, D. Shukla, “Structural rearrangement of the serotonin transporter intracellular gate induced by Thr276 phosphorylation”, ACS Chemical Neuroscience, 13(7), 933–945, (2022). DOI
Featured on the cover of ACS Chemical Neuroscience.
5. M. C. Chan*, B. Selvam*, H. J. Young, E. Procko, D. Shukla, “The substrate import mechanism of the human serotonin transporter”, Biophysical Journal, 121(5), 715–730, (2022). DOI
Featured on the cover of Biophysical Journal and the BPS Blog.
4. L. Zhang, S. Dutta*, S. Xiong*, M. Chan*, K. K. Chan, T. M. Fan, K. L. Bailey, M. Lindeblad, L. M. Cooper, L. Rong, others, “Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants”, Nature Chemical Biology, 18(3), 342–351, (2022). DOI
Featured in UIC Today and the NIH Director's Blog.
3. M. C. Chan, D. Shukla, “Markov state modeling of membrane transport proteins”, Journal of Structural Biology, 213(4), 107800, (2021). DOI
2. D. T. Bregante, M. C. Chan, J. Z. Tan, E. Z. Ayla, C. P. Nicholas, D. Shukla, D. W. Flaherty, “The shape of water in zeolites and its impact on oxidation catalysis”, Nature Catalysis, 4(9), 797–808, (2021). DOI
Featured in the Illinois News Bureau.
1. Z. Shamsi*, M. Chan*, D. Shukla, “TLmutation: Predicting the effects of mutations using transfer learning”, The Journal of Physical Chemistry B, 124(19), 3845–3854, (2020). DOI
Book Chapter
1. R. G. Hammond, X. Tan, M. Chan, A. Goel, M. A. Johnson, “Computational and experimental studies of ADP-ribosylation”, in Methods in Molecular Biology: Poly(ADP-Ribose) Polymerase, A. Tulin (ed.), Springer, 2017. DOI