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MATTHEW C. CHAN

Mahan Postdoctoral Fellow
Fred Hutchinson Cancer Research Center
Seattle, WA 98109
mchan3[at]fredhutch.org

Experience

Mahan Postdoctoral Fellow 2022 - Present
Fred Hutchinson Cancer Research Center Seattle, WA
Basic Sciences Division
Advisors: Arvind Rasi Subramaniam, Melody G. Campbell

Graduate Fellow 2017 - 2022
University of Illinois, Urbana-Champaign Urbana, IL
Department of Chemical and Biomolecular Engineering
Advisor: Diwakar Shukla

Undergraduate Research Assistant 2014 - 2017
The University of Alabama at Birmingham Birmingham, AL
Department of Chemistry
Advisor: Margaret A. Johnson

Education

Ph.D. Chemical and Biomolecular Engineering 2022
Dissertation: Molecular Mechanisms of Neurotransmitter Transport in Neurons
University of Illinois, Urbana-Champaign

M.S. Chemical and Biomolecular Engineering 2020
University of Illinois, Urbana-Champaign

B.S. Biomedical Engineering 2017
Double major: Applied Mathematics and Scientific Computation
magna cum luade, with Distugished Honors
The University of Alabama at Birmingham

Publications

Research Articles

  1. M. C. Chan, Y. Alfawaz, D. Shukla, "Molecular Mechanism of Substrate Transport and Dynamics of the Cyanobacterial Bicarbonate Transporter BicA", In review. Preprint

  2. M. C. Chan, D. Shukla, "The Effects of N-linked Glycosylation on SLC6 Transporters", In review. Preprint

  3. M. C. Chan, K. K. Chan, E. Procko, D. Shukla, "Machine Learning Guided Design of High Affinity ACE2 Decoys for SARS-CoV-2 Neutralization", In review. Preprint

  4. H. J. Young*, M. C. Chan*, B. Selvam, S. K. Szymanski, D. Shukla, E. Procko, "Deep Mutagenesis of a Neurotransmitter Transporter for Uptake of a Non-native Substrate Informs how Sequence Features Relate to Conformational Dynamics", In review. Preprint

  5. M. C. Chan, E. Procko, D. Shukla, "Structural Rearrangement of the Serotonin Intracellular Gate induced by Thr276 Phosphorylation", ACS Chemical Neuroscience, 13(7), 933-945, (2022). DOI

  6. M. C. Chan*, B. Selvam*, H. J. Young, E. Procko, D. Shukla, "The Substrate Import Mechanism of the Human Serotonin Transporter", Biophysical Journal, 121(5), 715-730, (2022). DOI

  7. L. Zhang, S. Dutta*, S. Xiong*, M. Chan*, K. K. Chan, T. M. Fan, K. L. Bailey, M. Lindebald, L. M. Cooper, L. Rong, A. F. Gugliuzza, D. Shukla, E. Procko, J. Rehman, A. B. Malik, "An Engineered High-Affinity ACE2 Peptide Therapeutically Mitigates Lung Vascular Injury and Mortality Induced by Distinct SARS-CoV-2 Variants", Nature Chemical Biology, 18(3), 342-351, (2022). DOI

  8. M. C. Chan, D. Shukla, "Markov State Modeling of Membrane Transport Proteins", Journal of Structural Biology, 213(4), 107800, (2021). DOI

  9. D. T. Bregante, M. C. Chan, J. Z. Tan, E. Z. Ayla, C. P. Nicholas, D. Shukla, D. W. Flaherty, "The Shape of Water in Zeolites and its Impact on Oxidation Catalysis", Nature Catalysis, 4(9), 797-808, (2021). DOI

  10. Z. Shamsi*, M. Chan*, D. Shukla, "TLmutation: Predicting the Effects of Mutations Using Transfer Learning", The Journal of Physical Chemistry B, 124 (19), 3845-3854, (2020). DOI

Book Chapter

  1. R. G. Hammond, X. Tan, M. Chan, A. Goel, M. A. Johnson, "Computational and Experimental Studies of ADP-Ribosylation", in Methods in Molecular Biology: Poly(ADP-Ribose) Polymerase, A. Tulin (ed.), Springer, 2017. DOI

Conference Presentations

Presented Talks

  1. Substrate Induced Conformational Transitions of the Human Serotonin Transporter, American Chemical Society National Meeting, San Diego, CA, August 2019.

  2. Substrate Import Mechanism of the Human Serotonin Transporter, Midwestern Thermodynamics and Statistical Mechanic Conference, University of Illinois, Urbana, IL, June 2019.

  3. Coronavirus Macrodomains: Bridging the gap between structure and function, 45th Annual Southeastern Magnetic Resonance Conference, Emory University, Atlanta, GA, October 2016.

Presented Posters

  1. M. C. Chan, H. J. Young, B. Selvam, S. K. Szymanski, E. Procko, D. Shukla, "Mechanism of Neurotransmitter Transport and Regulation Revealed by High Throughput Experiments and Simulations", 2nd Annual CAREER Awardee Conference, Molecular and Cellular Biosciences, National Science Foundation, Virtual Conference, November 2021.

  2. M. Chan, B. Selvam, H. J. Young, E. Procko, D. Shukla, "The Substrate Import Mechanism of the Human Serotonin Transporter", 18th Annual ChBE Graduate Student Symposium, University of Illinois, Urbana, IL, October 2019. 3rd prize poster presentation.

  3. M. Chan, B. Selvam, H. J. Young, E. Procko, D. Shukla, "The Substrate Import Mechanism of the Human Serotonin Transporter", Rare Events: Application, Computation, and Theory, Indian Institute of Science, Bangaluru, India, July 2019.

  4. M. Chan*, D. Chasteen-Boyd*, M. Collier*, S. Holder*, A. Eberhardt, "A Design for an Independent Alarm Clock for the Deaf-Blind", 10th Annual UAB Undergraduate Research Expo, University of Alabama at Birmingham, Birmingham, AL, April 2017.

  5. M. Chan*, D. Chasteen-Boyd*, M. Collier*, S. Holder*, A. Eberhardt, "A Design for an Independent Alarm Clock for the Deaf-Blind", 2017 Design for Medical Devices Conference, University of Minnesota, Minneapolis, MN, April 2017.

  6. M. Chan*, K. Villavicencio, R. G. Hammond, X. Tan, M. A. Johnson, "A Biochemical Investigation of Novel Noncanonical Coronavirus Macrodomains", 9th Annual UAB Undergraduate Research Expo, University of Alabama at Birmingham, Birmingham, AL, April 2016.

  7. M. Chan*, K. Hayes, R. G. Hammond, C. Tian, X. Tan, M. A. Johnson, "Biochemical Characterization of Noncanonical Coronavirus Macrodomains", 67th Southeastern Regional Meeting/ 71st Southwestern Regional Meeting of the American Chemical Society, Memphis, TN, November 2015.

  8. M. Chan*, R. G. Hammond, X. Tan, C. Tian, M. A. Johnson, "Characterization and Biochemical Analysis of Noncanonical Coronavirus Macrodomain", 2015 UAB Summer Resarch Expo, University of Alabama at Birmingham, Birmingham, AL, July 2015.

  9. M. Chan*, M. S. Pasala, R. G. Hammond, C. Tian, M. A. Johnson, "“Cloning, Expression, and Characterization of Recombinant Coronavirus Macrodomain", 2014 UAB Summer Resarch Expo, University of Alabama at Birmingham, Birmingham, AL, July 2014.

Teaching Assistantships

Heat and Mass Transfer, UIUC 2020
Process Controls and Dynamics, UIUC 2019
Rare Events Workshop, IISc, Bangalore, India 2019
Principles of Chemical Engineering, UIUC 2019
General Chemistry Lab, UAB 2014 - 2017
Engineering Graphics, UAB 2014

Honors & Awards

Mahan Postdoctoral Fellowship, Fred Hutch 2022
A.T. Widiger Chemical Engineering Fellowship, UIUC 2022
NSF MolSSI Graduate Student Seed Fellowship 2021
School of Chemical Sciences Image Challenge Finalist, UIUC 2020
List of Teachers Ranked Excellent, UIUC 2020
3rd Prize Poster Presentation, UIUC 2019
School of Chemical Sciences Graduate Teaching Award, UIUC 2019
List of Teachers Ranked Excellent, UIUC 2018
School of Chemical Sciences Image Challenge Finalist, UIUC 2018
DMD Student Design Showcase Finalist, University of Minnesota 2017
Francis J. Dupuis Engineering Scholarship, UAB 2014 - 2017
Jane Knight Lowe Fellow, UAB 2013 - 2017

Travel Awards

Office of Undergraduate Research Travel Grant, UAB 2017
School of Engineering Travel Award, UAB 2017
Southeast Magnetic Resonance Conference Student Travel Award 2016
Alabama Section of the ACS Undergraduate Student Travel Award 2015